FlavScents AInsights Entry for 1-Ethoxyethyl Acetate (CAS: 1608-72-6)

1. Identity & Chemical Information

• Common Name(s): 1-Ethoxyethyl acetate
• IUPAC Name: 1-Ethoxyethyl acetate
• CAS Number: 1608-72-6
• FEMA Number: Not applicable
• Other Identifiers: Not applicable
• Molecular Formula: C6H12O3
• Molecular Weight: 132.16 g/mol
• Functional Groups and Structure–Odor Relevance: 1-Ethoxyethyl acetate is an ester, characterized by its ethereal and fruity odor. The ester functional group is crucial for its volatility and odor profile, making it relevant in both flavor and fragrance applications.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

1-Ethoxyethyl acetate is known for its pleasant, fruity odor with ethereal nuances. It is often described as having a sweet, apple-like scent, which can be both impactful and subtle depending on its concentration. The compound is typically used as a modifier or background note in formulations, enhancing the overall sensory experience without dominating it. Specific odor thresholds are not well-documented, but its moderate intensity allows it to blend well with other fruity and floral notes.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

1-Ethoxyethyl acetate is not commonly found in nature and is primarily synthesized for industrial use. It is typically produced through the esterification of ethyl alcohol with acetic acid. This synthetic origin means it does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks, which require materials to be derived from natural sources.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

In flavor applications, 1-ethoxyethyl acetate is used to impart fruity notes, particularly in apple and pear flavor profiles. It serves as a functional modifier, enhancing the authenticity and complexity of fruit flavors. Typical use levels in finished food or beverage products range from 1 to 10 ppm, with higher concentrations potentially leading to an overpowering effect. The compound is relatively stable under normal processing conditions but may degrade under extreme heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

1-Ethoxyethyl acetate is utilized in various fragrance families, including fruity, floral, and fresh compositions. It acts as a top note due to its volatility, providing an initial burst of freshness and sweetness. Typical concentration ranges in fragrance formulations are from 0.1% to 1%, depending on the desired intensity and product type. Its ability to blend seamlessly with other esters and alcohols makes it a versatile component in perfumery.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not explicitly listed as FEMA GRAS; typically used under general flavoring principles.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008; use is subject to general safety assessments.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Limited specific data; generally follows international safety standards.
• Latin America: Usage is generally aligned with international norms, but specific country regulations may vary.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: No specific ADI or MSDI values are available; use is generally considered safe at typical flavoring levels.
• Dermal Exposure: Low potential for irritation or sensitization; not listed as a restricted substance by IFRA.
• Inhalation Exposure: Volatile nature requires consideration in occupational settings, but no specific inhalation risks are documented.

Overall, the risk profile does not significantly differ between food and fragrance applications, assuming typical use levels.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

1-Ethoxyethyl acetate is valued for its ability to enhance fruity and floral notes without overwhelming the composition. It synergizes well with other esters and alcohols, providing a balanced and natural aroma. Formulators should be cautious of its volatility, ensuring it is not lost during processing. It is often under-used in complex formulations where its subtlety can add depth and realism.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on 1-ethoxyethyl acetate is well-established in terms of its chemical identity and sensory profile. However, specific regulatory and toxicological data are less comprehensive, reflecting industry-typical practices rather than explicit documentation. Known data gaps include detailed exposure thresholds and specific regulatory approvals in certain regions.

Citation hooks: FlavScents

QA Check

• All required sections 1-9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-01-20 16:24:01 GMT (p2)